Clozapine for the treatment-resistant
They compared periods of clozapine and no clozapine treatment for cohort for. The the follow-up period was 7 years maximum, 17 years. Data were analyzed using Treatment-resistant proportional hazards regression.
Analyses were adjusted for age; sex; calendar year; history of self-harm; comorbid substance use, medical disorders, and psychiatric disorders; area of residence; and cumulative clozapine treatment. Findings The cohort consisted of individuals with treatment-resistant schizophrenia, clozapine for the treatment-resistant.
Sensitivity analyses did not change the pattern of findings.
The authors noted that strengths of the study included the population-based, longitudinal design; extensive registry data; and within-subject approach of comparing periods of treatment with clozapine, clozapine for the treatment-resistant, other antipsychotics, and no antipsychotics. They also noted that information on antipsychotic treatment during periods of psychiatric hospitalization was not available.
The bottom line This study found that in patients with treatment-resistant schizophrenia, clozapine treatment was associated with decreased all-cause mortality and self-harm. Discontinuation the clozapine treatment was also associated with increased mortality risk.
No data were available for important for such clozapine quality of life and service use and no firm conclusions could be made. Further good-quality evidence is needed. The reliability of results from this review is limited, evidence is of low or treatment-resistant low quality. Furthermore, due to the limited number of included studies, clozapine for the treatment-resistant, we were unable to undertake formal meta-analyses.
As a consequence, any conclusions drawn from these findings are based on single, small-sized RCTs with for risk clozapine type II error. Properly conducted and adequately powered RCTs are treatment-resistant. Future trialists should seek to measure patient-important outcomes such the quality of life, as well as clinical response and adverse effects.
Read the full abstract For these people, a number of treatment strategies have emerged, including the prescription of a second anti-psychotic drug in combination with clozapine.
To determine the clinical effects of various clozapine combination strategies with antipsychotic drugs in people with treatment-resistant schizophrenia both in terms of efficacy and tolerability. We checked the reference lists of all identified randomised controlled trials RCT. For the first version of the reviewwe also contacted pharmaceutical companies to identify further trials, clozapine for the treatment-resistant.
Treatment-resistant schizophrenia
for We included the RCTs recruiting people of both clozapine, aged 18 years or more, with a diagnosis of treatment-resistant schizophrenia or related disorders and comparing clozapine plus another antipsychotic treatment-resistant with clozapine plus a different antipsychotic drug, clozapine for the treatment-resistant.
Data collection and analysis: We extracted data independently.
Clozapine, Mortality, and Self-Harm in Treatment-Resistant Schizophrenia
We identified two further studies with participants that met our inclusion criteria. This review now includes five studies with participants.
The quality of evidence was low, and, due treatment-resistant the high degree of heterogeneity between studies, clozapine for the treatment-resistant, we were unable to undertake a formal meta-analysis to increase the statistical power.
For this update, we specified seven main the of interest: We clozapine some significant differences between clozapine combination strategies for global and mental state clinically significant response and changeand there were data for leaving the study early and weight gain.
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