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The answer is very simple, though not always obvious: Oral metronidazole has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathyhave been reported after 5 to 7 days of doses of 6 to Treatment Of Overdosage There is no prescription antidote for metronidazole overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.
Psychotic Reaction With Disulfiram Use of oral metronidazole is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently.
Interaction With Alcohol Use of oral metronidazole is associated with a disulfiram-like reaction to alcohol, including abdominal cramps, nausea, vomiting, headaches, and flushing.
Following oral administration, metronidazole is well absorbed, with peak plasma concentrations occurring between one and two hours after administration. Plasma concentrations out metronidazole are proportional to the administered dose.
Studies reveal no significant bioavailability differences between males and females; however, because of weight differences, the resulting plasma levels in males are generally lower. Distribution Metronidazole is the major component appearing in the plasma, with lesser quantities of metabolites also being present.
Metronidazole appears in cerebrospinal fluidsalivaand breast milk in concentrations similar to those found in plasma. Bactericidal concentrations of metronidazole have also been detected in pus from hepatic abscesses. Both the parent compound and the hydroxyl metabolite possess in vitro antimicrobial activity. The average elimination halflife of metronidazole in healthy subjects is eight hours. Renal Impairment Decreased renal function does not alter the singledose-pharmacokinetics of metronidazole.
Effect Of Dialysis Following a single intravenous infusion or oral dose of metronidazole mg, the clearance of metronidazole was investigated in ESRD subjects metronidazole hemodialysis or continuous ambulatory peritoneal dialysis CAPD. A peritoneal dialysis session lasting for 7. There were no significant changes in the AUC24 of hydroxylmetronidazole in these hepatically impaired patients, metronidazole out prescription.
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