Lotemax 5 mg - Lotemax % Eye Drops, Suspension - Summary of Product Characteristics (SmPC) - (eMC)
In those diseases causing thinning of the cornea or scleraperforations have been known to occur with the use of topical steroids. In acute purulent conditions of the eye, steroids may mask infection or enhance existing infection, lotemax 5 mg. Use of ocular steroids lotemax prolong the course and may exacerbate the severity of many viral infections of the eye including herpes simplex. Employment of a corticosteroid medication in the lotemax of patients with a history of herpes simplex requires great caution.
The use of steroids after cataract surgery lotemax delay healing and increase the incidence of bleb formation. For ophthalmic use only.
Lotemax ophthalmic suspension 0.5%
The initial prescription and renewal of the medication order beyond 14 days should be made by a physician only after examination of the patient with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, lotemax staining. If signs and symptoms fail to improve after two days, lotemax 5 mg, the patient should be re-evaluated.
If this product is used for 10 days or longer, intraocular pressure should be monitored even though it may be difficult in children and uncooperative patients see WARNINGS, lotemax 5 mg. Fungal infections of the cornea are particularly prone to develop coincidentally with long-term local steroid application. Fungus invasion must be considered in any persistent corneal ulceration where a steroid has been used or is in use.
Fungal cultures should be taken when appropriate. Carcinogenesis, mutagenesis, impairment of fertility: Long-term animal studies have not been conducted to evaluate the carcinogenic potential of loteprednol etabonate.
The initial prescription and renewal of the medication order beyond 14 days should be made by a physician only after examination of the patient with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, fluorescein staining. If signs and lotemax fail to improve after two days, lotemax 5 mg, the patient should be re-evaluated.
If this product is used for 10 days or longer, intraocular pressure should be monitored even though it may be difficult in children and uncooperative patients see WARNINGS, lotemax 5 mg.
Fungal infections of the cornea are particularly prone to develop coincidentally with long-term local steroid application. Fungus invasion must be considered in any persistent corneal ulceration where a steroid has been used or is in use.
Using Eye Drops to Treat Glaucoma
Fungal cultures should be taken when appropriate. Information for Patients This product is sterile when packaged. Patients should be advised not to allow the dropper tip to touch any surface, as this may contaminate the suspension. If pain develops, lotemax 5 mg, redness, itching or inflammation becomes aggravated, the patient should be advised to consult a physician.
Carcinogenesis, Mutagenesis, lotemax 5 mg, Impairment of Fertility Long-term animal studies have not been conducted to evaluate the carcinogenic potential of loteprednol lotemax. Loteprednol etabonate was not genotoxic in vitro in the Ames test, the mouse lymphoma tk assay, or in a chromosome aberration test in human lymphocytes, or in vivo in the single dose mouse micronucleus assay. The no-observed-effect-level NOEL for these effects was 0.
Treatment of rats with 0. Nursing Mothers It is not known whether topical ophthalmic administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk.
Loteprednol etabonate is a white to off-white powder. Loteprednol etabonate is represented by the following structural formula: Loteprednol Etabonate 5 mg lotemax. Clinical Pharmacology Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, lotemax 5 mg, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.
There is no generally accepted explanation for the mechanism of action of ocular corticosteroids.
However, corticosteroids are thought to act by the induction of phospholipase A 2 inhibitory proteins, lotemax 5 mg, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.
Arachidonic acid is released from membrane phospholipids by phospholipase A 2, lotemax 5 mg. Corticosteroids lotemax capable of producing a rise in intraocular pressure. Loteprednol etabonate is structurally similar to other corticosteroids. However, lotemax 5 mg, the number 20 position ketone group is absent. It is highly lipid soluble which enhances its penetration into cells. Loteprednol etabonate is synthesized through structural modifications of prednisolone-related compounds so that it will undergo a predictable transformation to an inactive metabolite, lotemax 5 mg.
If a patient presents with symptoms such as blurred vision or other visual disturbances, the patient should be considered for referral to an ophthalmologist for evaluation of possible causes which may include cataract, glaucoma or rare diseases such as central serous chorioretinopathy CSCR which have lotemax reported after use of systemic and topical corticosteroids. Prolonged use of corticosteroids may suppress the host response and may increase the possibility of secondary ocular infections.
In those diseases causing thinning lotemax the cornea or sclera, perforations have been known to occur with the use of topical steroids.
Lotemax 0.5% Eye Drops, Suspension
In acute purulent conditions of the eye, steroids may mask infection or enhance existing infection. Long term treating with corticosteroids can cause fungal disease. Fungal disease should be considered in the differential diagnosis when a corneal ulcer persists.
Lotemax contains benzalkonium chloride which may cause eye irritation. In general patients should not wear contact lenses after cataract surgery, unless contact lens wearing is medically indicated. Contact with soft contact lenses should be avoided, lotemax 5 mg.
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