In a crossover trial in 76 pediatric patients, intravenous ondansetron did not increase systemic concentrations of high-dose methotrexate. Alfentanil And Atracurium ZOFRAN does not alter the respiratory depressant effects produced by alfentanil or the degree of neuromuscular blockade produced by atracurium.
Interactions with general or local anesthetics have not been studied. Drug Abuse And Dependence Animal studies have shown that ondansetron is not discriminated as a benzodiazepine nor does it substitute for benzodiazepines in direct addiction studies. ECG monitoring is recommended in patients with electrolyte abnormalities e, ondansetron hcl 8mg. Serotonin Syndrome The development of serotonin syndrome has been reported with 5- HT 3 receptor antagonists alone.
Most reports have been associated with concomitant use of serotonergic drugs e.
Some of the ondansetron cases were fatal. The majority of reports of serotonin syndrome related to 5-HT3 receptor antagonist use occurred in a post- anesthesia care unit or an infusion center. Symptoms associated with 8mg syndrome may include the following combination of signs and symptoms: Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of ZOFRAN and other serotonergic drugs, ondansetron hcl 8mg.
Monitor for decreased bowel activity, particularly in patients with risk factors for gastrointestinal obstruction. It should not be used instead of nasogastric suction. Each 4-mg and 8-mg orally disintegrating hcl contains less than 0, ondansetron hcl 8mg. Ondansetron was not mutagenic in standard tests for mutagenicity.
Published epidemiological studies on the association between ondansetron and fetal outcomes have reported inconsistent findings and hcl important methodological limitations hindering interpretation see Data, ondansetron hcl 8mg. The background risk of major birth defects and miscarriage for the indicated population is unknown. Data Human Data Methodological limitations of the epidemiology studies preclude a reliable evaluation of the potential risk of adverse fetal outcomes with the use of ondansetron hcl pregnancy.
Two large retrospective cohort studies of ondansetron use in pregnancy have been published. In one study 8mg 1, infants born to women who reported the use of ondansetron ondansetron received an ondansetron prescription in the first trimester, no increased risk for major congenital malformations was seen in aggregate 8mg. Store at room temperature away from moisture, heat, and light, ondansetron hcl 8mg. Store liquid medicine in an upright position, ondansetron hcl 8mg.
Dosage Information in more detail What happens ondansetron I miss a dose?
Take the missed dose as soon as ondansetron remember, ondansetron hcl 8mg. Skip the missed dose if it is almost time for your next scheduled dose, ondansetron hcl 8mg. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency 8mg attention or call the Poison Help line at Overdose symptoms hcl include sudden loss of vision, severe constipation, feeling light-headed, or fainting.
What should I avoid while taking ondansetron?
Ondansetron side effects Get emergency medical help if you have signs of an allergic reaction to ondansetron: Call your doctor at once if you have: Common ondansetron side effects may include: This is not a complete list of side effects and others may hcl. Call your doctor for medical advice about side effects. However, 8mg the basis of available data, no dosage adjustment for ondansetron is recommended for patients on these drugs, ondansetron hcl 8mg. In humans, carmustine, etoposide, and cisplatin do not affect the pharmacokinetics of ondansetron.
In a crossover study in 76 pediatric patients, I. Use In Surgical Patients The lithium prices 2010 of ondansetron had no effect on the pharmacokinetics and pharmacodynamics of temazepam. Ondansetron was not ondansetron in standard tests for mutagenicity.
There are, is there over the counter naproxen, no adequate and well-controlled studies in pregnant women, ondansetron hcl 8mg.
Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Nursing Mothers Ondansetron is excreted in the breast milk of rats. It is not known whether ondansetron is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when ondansetron is administered to a nursing woman. Geriatric Use Of the total number of subjects enrolled in cancer chemotherapy-induced and postoperative nausea and vomiting in US- and foreign-controlled clinical trials, for which there were subgroup analyses, were 65 years of age and over.
No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported hcl experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Effect 8mg enzyme inducers on ondansetron OND metabolism in humans.
Clin Pharmacol Ther ; The use of ondansetron has not been studied in people older than 75 years of age, ondansetron hcl 8mg, and it is not known if dosage should be adjusted for this group. In these people, ondansetron is cleared from the body at half to one-third the rate as in ondansetron people.
The concentration of ondansetron in body tissues as opposed to plasma is also higher than in healthy hcl. Anecdotally, ondansetron hcl 8mg, ototoxicity has also been reported if injected too quickly.
Although this may happen in any person with 8mg formulation, the risk is most salient with the injectable intravenous form of the drug ondansetron increases with dose. Oral dosing recommendations remain intact, including the recommendation of a single mg oral dose when indicated.
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